6PF6
Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)terephthalic acid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A, C, D | Thymidylate synthase,Thymidylate synthase | polymer | 290 | 33189.1 | 4 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens (Human) | TSase,TSase |
2 | B, A, C, D | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 4 | Chemie (UMP) | |||
3 | B, C | 2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)benzene-1,4-dicarboxylic acid | non-polymer | 447.4 | 2 | Chemie (OEJ) | |||
4 | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 132756.3 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 2127.5 | |
All* | Total formula weight | 134883.8 |