6PF6

Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)terephthalic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (B, A, C, D)	Thymidylate synthase,Thymidylate synthase	polymer	290	33189.1	4	UniProt (P04818) Pfam (PF00303)	Homo sapiens (Human)	TSase,TSase
2	E, G, H, J (B, A, C, D)	2'-DEOXYURIDINE 5'-MONOPHOSPHATE	non-polymer		308.2	4	Chemie (UMP)
3	F, I (B, C)	2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)benzene-1,4-dicarboxylic acid	non-polymer		447.4	2	Chemie (OEJ)
4	K, L, M, N (B, A, C, D)	water	water		18.0	22	Chemie (HOH)

Sequence modifications

B, A, C, D: 1 - 6 (UniProt: P04818)
B, A, C, D: 30 - 313 (UniProt: P04818)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	132756.3
Non-Polymers*	Number of molecules	6
	Total formula weight	2127.5
All*	Total formula weight	134883.8

*Water molecules are not included.