6PDD
Crystal structure of MYST acetyltransferase domain in complex with inhibitor 41
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Histone acetyltransferase KAT8 | polymer | 272 | 31941.8 | 1 | UniProt (Q9H7Z6) Pfam (PF17772) Pfam (PF01853) In PDB | Homo sapiens (Human) | Lysine acetyltransferase 8,MOZ,YBF2/SAS3,SAS2 and TIP60 protein 1,hMOF |
| 2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | A | 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-[(propan-2-yl)oxy]benzohydrazide | non-polymer | 366.4 | 1 | Chemie (O9S) | |||
| 5 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | water | water | 18.0 | 197 | Chemie (HOH) |
Sequence modifications
A: 507 - 778 (UniProt: Q9H7Z6)
| PDB | External Database | Details |
|---|---|---|
| His 579 | Tyr 249 | conflict |
| Ser 645 | Ala 315 | engineered mutation |
| Met 648 | Leu 318 | engineered mutation |
| Ile 649 | Thr 319 | engineered mutation |
| Arg 660 | Lys 330 | engineered mutation |
| Ser 697 | Trp 367 | engineered mutation |
| Asn 702 | Ile 372 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31941.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 735.1 | |
| All* | Total formula weight | 32676.9 |
