6PDB
Crystal structure of MYST acetyltransferase domain in complex with inhibitor 80
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Histone acetyltransferase KAT8 | polymer | 272 | 31941.8 | 1 | UniProt (Q9H7Z6) Pfam (PF17772) Pfam (PF01853) In PDB | Homo sapiens (Human) | Lysine acetyltransferase 8,MOZ,YBF2/SAS3,SAS2 and TIP60 protein 1,hMOF |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
5 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
6 | A | 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(pyrimidin-2-yl)benzohydrazide | non-polymer | 386.4 | 1 | Chemie (O9M) | |||
7 | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A: 507 - 778 (UniProt: Q9H7Z6)
PDB | External Database | Details |
---|---|---|
His 579 | Tyr 249 | conflict |
Ser 645 | Ala 315 | engineered mutation |
Met 648 | Leu 318 | engineered mutation |
Ile 649 | Thr 319 | engineered mutation |
Arg 660 | Lys 330 | engineered mutation |
Ser 697 | Trp 367 | engineered mutation |
Asn 702 | Ile 372 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 31941.8 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 755.0 | |
All* | Total formula weight | 32696.8 |