6PA7
The cryo-EM structure of the human DNMT3A2-DNMT3B3 complex bound to nucleosome.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, E | Histone H3.2 | polymer | 135 | 15303.9 | 2 | UniProt (P84233) Pfam (PF00125) In PDB | Xenopus laevis (African clawed frog) | |
2 | B, F | Histone H4 | polymer | 103 | 11394.4 | 2 | UniProt (P62799) Pfam (PF15511) In PDB | Xenopus laevis (African clawed frog) | |
3 | C, G | Histone H2A type 1 | polymer | 129 | 13978.2 | 2 | UniProt (P06897) Pfam (PF00125) Pfam (PF16211) In PDB | Xenopus laevis (African clawed frog) | |
4 | D, H | Histone H2B 1.1 | polymer | 123 | 13655.9 | 2 | UniProt (P02281) Pfam (PF00125) In PDB | Xenopus laevis (African clawed frog) | H2B1.1 |
5 | I | DNA (167-MER) | polymer | 167 | 51327.7 | 1 | synthetic construct | ||
6 | J | DNA (167-MER) | polymer | 167 | 51786.0 | 1 | synthetic construct | ||
7 | K, P | DNA (cytosine-5)-methyltransferase 3A | polymer | 689 | 77914.7 | 2 | UniProt (Q9Y6K1) Pfam (PF00855) Pfam (PF17980) Pfam (PF21255) Pfam (PF00145) In PDB | Homo sapiens (Human) | Dnmt3a,DNA methyltransferase HsaIIIA,M.HsaIIIA |
8 | N, S | DNA (cytosine-5)-methyltransferase 3B | polymer | 770 | 86294.9 | 2 | UniProt (Q9UBC3) Pfam (PF00855) Pfam (PF17980) Pfam (PF21255) Pfam (PF00145) In PDB | Homo sapiens (Human) | Dnmt3b,DNA methyltransferase HsaIIIB,M.HsaIIIB |
9 | A, C, H | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
10 | K, P | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) |
Sequence modifications
A, E: 1 - 135 (UniProt: P84233)
C, G: 1 - 129 (UniProt: P06897)
D, H: 1 - 122 (UniProt: P02281)
PDB | External Database | Details |
---|---|---|
Ala 102 | Gly 103 | conflict |
PDB | External Database | Details |
---|---|---|
Arg 99 | Gly 100 | conflict |
Ser 123 | Ala 124 | conflict |
PDB | External Database | Details |
---|---|---|
Met 0 | - | initiating methionine |
Thr 29 | Ser 33 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 14 |
Total formula weight | 540198.0 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 875.2 | |
All* | Total formula weight | 541073.2 |