6P9Y

PAC1 GPCR Receptor complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	polymer	394	45700.4	1	UniProt (P63092) Pfam (PF00503) In PDB	Homo sapiens (Human)	Adenylate cyclase-stimulating G alpha protein
2	B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	350	38534.1	1	UniProt (P62873) Pfam (PF00400) In PDB	Homo sapiens (Human)	Transducin beta chain 1
3	G	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631) In PDB	Homo sapiens (Human)	G gamma-I
4	N	Nanobody 35	polymer	138	15140.7	1		Lama glama (llama)
5	P	Pituitary adenylate cyclase-activating polypeptide	polymer	39	4545.3	1	UniProt (P18509) Pfam (PF00123) In PDB	Homo sapiens	PACAP
6	R	Pituitary adenylate cyclase-activating polypeptide type I receptor	polymer	483	55439.2	1	UniProt (P41586) Pfam (PF02793) Pfam (PF00002) In PDB	Homo sapiens (Human)	PACAP-R1

Sequence modifications

A: 1 - 394 (UniProt: P63092)

PDB	External Database	Details
Lys 271	Asn 271	conflict
Asp 274	Lys 274	conflict
Lys 280	Arg 280	conflict
Asp 284	Thr 284	conflict
Thr 285	Ile 285	conflict

B: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Met -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
Gly 1	-	expression tag

P: 1 - 38 (UniProt: P18509)

PDB	External Database	Details
Nh2 39	-	amidation

R: 19 - 468 (UniProt: P41586)

PDB	External Database	Details
Asp 5	-	expression tag
Tyr 6	-	expression tag
Lys 7	-	expression tag
Asp 8	-	expression tag
Asp 9	-	expression tag
Asp 10	-	expression tag
Asp 11	-	expression tag
Leu 12	-	expression tag
Glu 13	-	expression tag
Val 14	-	expression tag
Leu 15	-	expression tag
Phe 16	-	expression tag
Gln 17	-	expression tag
Gly 18	-	expression tag
Pro 469	-	expression tag
Ala 470	-	expression tag
Gly 471	-	expression tag
Leu 472	-	expression tag
Glu 473	-	expression tag
Val 474	-	expression tag
Leu 475	-	expression tag
Phe 476	-	expression tag
Gln 477	-	expression tag
Gly 478	-	expression tag
Pro 479	-	expression tag
His 480	-	expression tag
His 481	-	expression tag
His 482	-	expression tag
His 483	-	expression tag
His 484	-	expression tag
His 485	-	expression tag
His 486	-	expression tag
His 487	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	167220.9
All*	Total formula weight	167220.9

*Water molecules are not included.