6P91
Structure of Lassa virus glycoprotein bound to Fab 18.5C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Pre-glycoprotein polyprotein GP complex | polymer | 257 | 28784.0 | 1 | UniProt (Q6GWS0) Pfam (PF00798) UniProt (by SIFTS) (P08669) | Lassa mammarenavirus | Pre-GP-C |
| 2 | B (H) | Fab 18.5C Antibody heavy chain | polymer | 228 | 24309.4 | 1 | Homo sapiens | ||
| 3 | C (L) | Fab 18.5C Antibody light chain | polymer | 217 | 23654.2 | 1 | Homo sapiens | ||
| 4 | D (a) | Pre-glycoprotein polyprotein GP complex,Lassa virus glycoprotein, GP2 subunit | polymer | 200 | 22750.4 | 1 | UniProt (Q6GWS0) Pfam (PF00798) UniProt (by SIFTS) (P08669) | Lassa mammarenavirus | Pre-GP-C |
| 5 | E, K (B, I) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
| 6 | F, G, I, J (C, D, F, G) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 7 | H, L (E, J) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 8 | M (K) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
| 9 | N (a) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
A: 1 - 257 (UniProt: Q6GWS0)
a: 260 - 424 (UniProt: Q6GWS0)
a: 425 - 459 (PDB: 6P91)
| PDB | External Database | Details |
|---|---|---|
| Cys 207 | Arg 207 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Pro 329 | Glu 329 | engineered mutation |
| Thr 332 | Met 332 | engineered mutation |
| Cys 360 | Gly 360 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 99498.1 | |
| Branched | Number of molecules | 9 |
| Total formula weight | 5100.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 104820.0 |
