6P7I
Crystal structure of Human PRMT6 in complex with S-Adenosyl-L-Homocysteine and YS17-117 Compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Protein arginine N-methyltransferase 6 | polymer | 376 | 42074.6 | 4 | UniProt (Q96LA8) Pfam (PF13649) Pfam (PF22528) | Homo sapiens (Human) | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6,Histone-arginine N-methyltransferase PRMT6 |
| 2 | E, H, K, M (A, B, C, D) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) | |||
| 3 | F, I, L (A, B, C) | N-[3-(4-{[(2-aminoethyl)(methyl)amino]methyl}-1H-pyrrol-3-yl)phenyl]prop-2-enamide | non-polymer | 298.4 | 3 | Chemie (O3P) | |||
| 4 | G, J (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | N (D) | N-[3-(4-{[(2-aminoethyl)(methyl)amino]methyl}-1H-pyrrol-3-yl)phenyl]propanamide | non-polymer | 300.4 | 1 | Chemie (O3S) | |||
| 6 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 759 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 375 (UniProt: Q96LA8)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Val 194 | Ala 194 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 168298.2 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2917.4 | |
| All* | Total formula weight | 171215.6 |
