6P6W
Cryo-EM structure of voltage-gated sodium channel NavAb N49K/L109A/M116V/G94C/Q150C disulfide crosslinked mutant in the resting state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Fusion of Maltose-binding protein and voltage-gated sodium channel NavAb | polymer | 661 | 74072.8 | 4 | UniProt (A0A028ANC5) UniProt (A8EVM5) Pfam (PF01547) Pfam (PF00520) Pfam (PF08016) UniProt (by SIFTS) (P0AEX9) | Escherichia coli K-12 | dihydrodipicolinate synthase |
Sequence modifications
A, B, C, D: 607 - 998 (UniProt: A0A028ANC5)
A, B, C, D: 1001 - 1267 (UniProt: A8EVM5)
| PDB | External Database | Details |
|---|---|---|
| Asn 999 | - | linker |
| Ala 1000 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 1004 | Arg 4 | engineered mutation |
| Lys 1049 | Asn 49 | engineered mutation |
| Cys 1094 | Gly 94 | engineered mutation |
| Ala 1109 | Leu 109 | engineered mutation |
| Val 1116 | Met 116 | engineered mutation |
| Cys 1150 | Gln 150 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 296291.2 | |
| All* | Total formula weight | 296291.2 |
