6P6W

Cryo-EM structure of voltage-gated sodium channel NavAb N49K/L109A/M116V/G94C/Q150C disulfide crosslinked mutant in the resting state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Fusion of Maltose-binding protein and voltage-gated sodium channel NavAb	polymer	661	74072.8	4	UniProt (A0A028ANC5) UniProt (A8EVM5) Pfam (PF01547) Pfam (PF00520) UniProt (by SIFTS) (P0AEX9) In PDB	Escherichia coli K-12	dihydrodipicolinate synthase

Sequence modifications

A, B, C, D: 607 - 998 (UniProt: A0A028ANC5)

PDB	External Database	Details
Asn 999	-	linker
Ala 1000	-	linker

A, B, C, D: 1001 - 1267 (UniProt: A8EVM5)

PDB	External Database	Details
Ala 1004	Arg 4	engineered mutation
Lys 1049	Asn 49	engineered mutation
Cys 1094	Gly 94	engineered mutation
Ala 1109	Leu 109	engineered mutation
Val 1116	Met 116	engineered mutation
Cys 1150	Gln 150	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	296291.2
All*	Total formula weight	296291.2

*Water molecules are not included.