6P4V
1.65 Angstrom ternary complex of Deoxyhypusine synthase with cofactor NAD and spermidine mimic inhibitor GC7
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Deoxyhypusine synthase | polymer | 372 | 41213.6 | 2 | UniProt (P49366) Pfam (PF01916) | Homo sapiens (Human) | DHS |
| 2 | C, F (A, B) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 2 | Chemie (NAD) | |||
| 3 | D, G (A, B) | 1-GUANIDINIUM-7-AMINOHEPTANE | non-polymer | 174.3 | 2 | Chemie (GC7) | |||
| 4 | E (A) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 326 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 369 (UniProt: P49366)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 82427.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1793.6 | |
| All* | Total formula weight | 84220.8 |
