6P3P
Crystal structure of Mcl-1 in complex with compound 65
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 157 | 17880.3 | 1 | UniProt (Q07820) Pfam (PF00452) In PDB | Homo sapiens (Human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
| 2 | A | methyl N-(5-{[2-chloro-5-(trifluoromethyl)phenyl]sulfamoyl}-4-methylthiophene-2-carbonyl)-D-phenylalaninate | non-polymer | 561.0 | 1 | Chemie (NQJ) | |||
| 3 | water | water | 18.0 | 99 | Chemie (HOH) |
Sequence modifications
A: 171 - 327 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Ser 171 | Glu 171 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17880.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 561.0 | |
| All* | Total formula weight | 18441.3 |
