6OYW
ASK1 kinase domain in complex with Compound 11
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Mitogen-activated protein kinase kinase kinase 5 | polymer | 294 | 33064.7 | 4 | UniProt (Q99683) Pfam (PF00069) | Homo sapiens (Human) | Apoptosis signal-regulating kinase 1,ASK-1,MAPK/ERK kinase kinase 5,MEKK 5 |
| 2 | E, F, G, I (A, B, C, D) | (19S)-19-methyl-16,17,18,19-tetrahydro-8,4-(azeno)[1,2,4]triazolo[4,3-f][1,6,13]benzoxadiazacyclohexadecin-10(9H)-one | non-polymer | 349.4 | 4 | Chemie (NKJ) | |||
| 3 | H (C) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 252 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 658 - 951 (UniProt: Q99683)
| PDB | External Database | Details |
|---|---|---|
| Glu 838 | Thr 838 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 132258.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1421.8 | |
| All* | Total formula weight | 133680.6 |
