6OYT
ASK1 kinase domain in complex with GS-4997
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Mitogen-activated protein kinase kinase kinase 5 | polymer | 280 | 31702.1 | 4 | UniProt (Q99683) Pfam (PF00069) | Homo sapiens (Human) | Apoptosis signal-regulating kinase 1,ASK-1,MAPK/ERK kinase kinase 5,MEKK 5 |
| 2 | E, G, K, N (A, B, C, D) | 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}benzamide | non-polymer | 445.5 | 4 | Chemie (NJV) | |||
| 3 | F, H, I, J, L... (A, B, C, D) | ACETATE ION | non-polymer | 59.0 | 9 | Chemie (ACT) | |||
| 4 | R, S, T, U (A, B, C, D) | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 667 - 939 (UniProt: Q99683)
| PDB | External Database | Details |
|---|---|---|
| Met 666 | - | initiating methionine |
| His 940 | - | expression tag |
| His 941 | - | expression tag |
| His 942 | - | expression tag |
| His 943 | - | expression tag |
| His 944 | - | expression tag |
| His 945 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 126808.4 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 2313.4 | |
| All* | Total formula weight | 129121.8 |
