6OX3

SETD3 in Complex with an Actin Peptide with His73 Replaced with Lysine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (Y, Z)	Actin Peptide	polymer	19	2283.6	2	UniProt (C9JUM1) UniProt (by SIFTS) (P60709)	Homo sapiens
2	B, D (A, B)	Histone-lysine N-methyltransferase setd3	polymer	599	67753.5	2	UniProt (Q86TU7) Pfam (PF00856) Pfam (PF09273)	Homo sapiens (Human)	SET domain-containing protein 3
3	E, G, H, I, J (Y, A)	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
4	F, HA (A, B)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)
5	AA, BA, CA, DA, EA... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	34	Chemie (EDO)
6	GA (A)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
7	UA (B)	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
8	VA, WA, XA, YA (Y, A, Z, B)	water	water		18.0	594	Chemie (HOH)

Sequence modifications

Y, Z: 66 - 84 (UniProt: C9JUM1)

PDB	External Database	Details
Lys 73	His 73	engineered mutation

A, B: 0 - 593 (UniProt: Q86TU7)

PDB	External Database	Details
Gly -5	-	expression tag
Pro -4	-	expression tag
Leu -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	140074.3
Non-Polymers*	Number of molecules	43
	Total formula weight	3548.8
All*	Total formula weight	143623.1

*Water molecules are not included.