6OWH
Crystal structure of MYST acetyltransferase domain in complex with inhibitor 92
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Histone acetyltransferase KAT8 | polymer | 273 | 32140.1 | 1 | UniProt (Q9H7Z6) Pfam (PF17772) Pfam (PF01853) In PDB | Homo sapiens (Human) | Lysine acetyltransferase 8,MOZ,YBF2/SAS3,SAS2 and TIP60 protein 1,hMOF |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
4 | A | N'-[(2-fluorophenyl)sulfonyl]-3-iodobenzohydrazide | non-polymer | 420.2 | 1 | Chemie (NBJ) | |||
5 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
6 | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A: 506 - 778 (UniProt: Q9H7Z6)
PDB | External Database | Details |
---|---|---|
His 579 | Tyr 249 | conflict |
Ser 645 | Ala 315 | engineered mutation |
Met 648 | Leu 318 | engineered mutation |
Ile 649 | Thr 319 | engineered mutation |
Arg 660 | Lys 330 | engineered mutation |
Asn 702 | Ile 372 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 32140.1 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 747.9 | |
All* | Total formula weight | 32888.0 |