6OVA
Crystal Structure of TYK2 with novel pyrrolidinone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Non-receptor tyrosine-protein kinase TYK2 | polymer | 301 | 34844.9 | 1 | UniProt (P29597) Pfam (PF07714) | Homo sapiens (Human) | |
| 2 | B (A) | 6-({4-[(3S)-3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl]pyridin-2-yl}amino)-N,N-dimethylpyridine-3-carboxamide | non-polymer | 390.4 | 1 | Chemie (N9G) | |||
| 3 | C (A) | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A: 884 - 1176 (UniProt: P29597)
| PDB | External Database | Details |
|---|---|---|
| Met 882 | - | initiating methionine |
| Gly 883 | - | expression tag |
| Ser 1016 | Ala 1016 | conflict |
| Asn 1023 | Asp 1023 | conflict |
| His 1177 | - | expression tag |
| His 1178 | - | expression tag |
| His 1179 | - | expression tag |
| His 1180 | - | expression tag |
| His 1181 | - | expression tag |
| His 1182 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34844.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 390.4 | |
| All* | Total formula weight | 35235.3 |
