6OSH

Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	L	Antibody Light chain variable region	polymer	113	11957.3	1		Oryctolagus cuniculus
2	K	Tyrosine-protein kinase transmembrane receptor ROR2	polymer	96	10688.8	1	UniProt (Q01974) Pfam (PF00051) In PDB	Homo sapiens (Human)	Neurotrophic tyrosine kinase,receptor-related 2
3	H	Antibody heavy chain variable region	polymer	114	12372.8	1		Oryctolagus cuniculus
4		water	water		18.0	426	Chemie (HOH)

Sequence modifications

K: 314 - 394 (UniProt: Q01974)

PDB	External Database	Details
Met 299	-	initiating methionine
Gly 300	-	expression tag
Ser 301	-	expression tag
His 302	-	expression tag
His 303	-	expression tag
His 304	-	expression tag
His 305	-	expression tag
His 306	-	expression tag
His 307	-	expression tag
Leu 308	-	expression tag
Val 309	-	expression tag
Pro 310	-	expression tag
Arg 311	-	expression tag
Gly 312	-	expression tag
Ser 313	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	35018.8
All*	Total formula weight	35018.8

*Water molecules are not included.