6OSH
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Antibody Light chain variable region | polymer | 113 | 11957.3 | 1 | Oryctolagus cuniculus | ||
| 2 | B (K) | Tyrosine-protein kinase transmembrane receptor ROR2 | polymer | 96 | 10688.8 | 1 | UniProt (Q01974) Pfam (PF00051) | Homo sapiens (Human) | Neurotrophic tyrosine kinase,receptor-related 2 |
| 3 | C (H) | Antibody heavy chain variable region | polymer | 114 | 12372.8 | 1 | Oryctolagus cuniculus | ||
| 4 | D, E, F (L, K, H) | water | water | 18.0 | 426 | Chemie (HOH) |
Sequence modifications
K: 314 - 394 (UniProt: Q01974)
| PDB | External Database | Details |
|---|---|---|
| Met 299 | - | initiating methionine |
| Gly 300 | - | expression tag |
| Ser 301 | - | expression tag |
| His 302 | - | expression tag |
| His 303 | - | expression tag |
| His 304 | - | expression tag |
| His 305 | - | expression tag |
| His 306 | - | expression tag |
| His 307 | - | expression tag |
| Leu 308 | - | expression tag |
| Val 309 | - | expression tag |
| Pro 310 | - | expression tag |
| Arg 311 | - | expression tag |
| Gly 312 | - | expression tag |
| Ser 313 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 35018.8 | |
| All* | Total formula weight | 35018.8 |
