6OS1
Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to TRV023
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Type-1 angiotensin II receptor,Soluble cytochrome b562 BRIL fusion protein | polymer | 425 | 48514.9 | 1 | UniProt (P30556) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) | Homo sapiens (Human) | AT1AR,AT1BR,Angiotensin II type-1 receptor,AT1,Cytochrome b-562 |
| 2 | B (D) | Nanobody Nb.AT110i1_le | polymer | 128 | 13796.1 | 1 | synthetic construct | ||
| 3 | C (B) | TRV023 peptide | polymer | 8 | 944.1 | 1 | synthetic construct | ||
| 4 | D, E, F, G, H... (A) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 6 | Chemie (OLC) | |||
| 5 | J (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 6 | K, L (A, D) | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
A: 2 - 226 (UniProt: P30556)
A: 227 - 1226 (UniProt: P0ABE7)
A: 1227 - 1319 (UniProt: P30556)
| PDB | External Database | Details |
|---|---|---|
| Asp -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Lys -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Lys 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Trp 232 | Met 29 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 63255.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2525.9 | |
| All* | Total formula weight | 65781.1 |
