6OQM

crystal structure of the MSH6 PWWP domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	DNA mismatch repair protein Msh6	polymer	130	15145.2	1	UniProt (P52701) Pfam (PF00855)	Homo sapiens (Human)	hMSH6,G/T mismatch-binding protein,GTMBP,MutS protein homolog 6,MutS-alpha 160 kDa subunit,p160
2	B, H, I, J (A)	UNKNOWN LIGAND	non-polymer			4	Chemie (UNX)
3	C (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
4	D, E, F, G (A)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
5	K (A)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A: 87 - 198 (UniProt: P52701)

PDB	External Database	Details
Met 69	-	initiating methionine
His 70	-	expression tag
His 71	-	expression tag
His 72	-	expression tag
His 73	-	expression tag
His 74	-	expression tag
His 75	-	expression tag
Ser 76	-	expression tag
Ser 77	-	expression tag
Gly 78	-	expression tag
Arg 79	-	expression tag
Glu 80	-	expression tag
Asn 81	-	expression tag
Leu 82	-	expression tag
Tyr 83	-	expression tag
Phe 84	-	expression tag
Gln 85	-	expression tag
Gly 86	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	15145.2
Non-Polymers*	Number of molecules	9
	Total formula weight	408.6
All*	Total formula weight	15553.7

*Water molecules are not included.