6OPZ

HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, I54L, A71V, L76V, V82F, I84V Mutant in complex with darunavir

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Protease NL4-3	polymer	99	10951.9	2	UniProt (Q7ZCL2) Pfam (PF00077) UniProt (by SIFTS) (P12497) In PDB	Human immunodeficiency virus 1
2	A	(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE	non-polymer		547.7	1	Chemie (017)
3		water	water		18.0	97	Chemie (HOH)

Sequence modifications

A, B: 1 - 99 (UniProt: Q7ZCL2)

PDB	External Database	Details
Lys 7	Gln 7	engineered mutation
Val 13	Ile 13	engineered mutation
Glu 16	Gly 16	engineered mutation
Phe 33	Leu 33	engineered mutation
Lys 43	Arg 43	engineered mutation
Ile 45	Lys 45	engineered mutation
Leu 54	Val 54	engineered mutation
Val 76	Leu 76	engineered mutation
Phe 82	Ala 82	engineered mutation
Val 84	Ile 84	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	21903.8
Non-Polymers*	Number of molecules	1
	Total formula weight	547.7
All*	Total formula weight	22451.5

*Water molecules are not included.