6OPW
HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, A71V, V82F, I84V Mutant in complex with darunavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Protease NL4-3 | polymer | 99 | 10965.9 | 2 | UniProt (Q7ZCI0) UniProt (by SIFTS) (P12497) | Human immunodeficiency virus 1 | |
| 2 | C (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | D (A) | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 1 | Chemie (017) PubChem (44400512) PubChem (44578485) PubChem (23545473) PubChem (52949690) PubChem (213039) PubChem (58330571) PubChem (60170302) PubChem (70329566) PubChem (66725685) PubChem (89334570) PubChem (3001874) PubChem (89394603) PubChem (102206609) PubChem (6320435) PubChem (125136514) PubChem (6320436) PubChem (6320437) PubChem (101897907) PubChem (102206607) PubChem (102206608) PubChem (118243427) PubChem (118243428) PubChem (118243429) PubChem (125136515) PubChem (129010372) PubChem (131632443) PubChem (131667685) PubChem (134694394) PubChem (137704505) PubChem (137704865) PubChem (138631483) PubChem (138631484) PubChem (138631622) PubChem (144227995) PubChem (145507139) PubChem (147231834) PubChem (156183881) PubChem (156183911) PubChem (171370671) | |||
| 4 | E, F (B, A) | water | water | 18.0 | 131 | Chemie (HOH) |
Sequence modifications
B, A: 1 - 99 (UniProt: Q7ZCI0)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
| Val 13 | Ile 13 | engineered mutation |
| Glu 16 | Gly 16 | engineered mutation |
| Ile 32 | Val 32 | engineered mutation |
| Phe 33 | Leu 33 | engineered mutation |
| Ile 45 | Lys 45 | engineered mutation |
| Ile 46 | Met 46 | engineered mutation |
| Val 71 | Ala 71 | engineered mutation |
| Phe 82 | Val 82 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21931.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 643.7 | |
| All* | Total formula weight | 22575.6 |
