6OPW

HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, A71V, V82F, I84V Mutant in complex with darunavir

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	Protease NL4-3	polymer	99	10965.9	2	UniProt (Q7ZCI0) Pfam (PF00077) UniProt (by SIFTS) (P12497) In PDB	Human immunodeficiency virus 1
2	B	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
3	A	(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE	non-polymer		547.7	1	Chemie (017)
4		water	water		18.0	131	Chemie (HOH)

Sequence modifications

B, A: 1 - 99 (UniProt: Q7ZCI0)

PDB	External Database	Details
Lys 7	Gln 7	engineered mutation
Val 13	Ile 13	engineered mutation
Glu 16	Gly 16	engineered mutation
Ile 32	Val 32	engineered mutation
Phe 33	Leu 33	engineered mutation
Ile 45	Lys 45	engineered mutation
Ile 46	Met 46	engineered mutation
Val 71	Ala 71	engineered mutation
Phe 82	Val 82	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	21931.8
Non-Polymers*	Number of molecules	2
	Total formula weight	643.7
All*	Total formula weight	22575.6

*Water molecules are not included.