6OOU

Crystal structure of HIV-1 Protease NL4-3 L89V Mutant in complex with darunavir

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	NL4-3 PROTEASE	polymer	99	10817.8	2	UniProt (Q7ZCR0) Pfam (PF00077) UniProt (by SIFTS) (P12497) In PDB	Human immunodeficiency virus 1
2	A	(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE	non-polymer		547.7	1	Chemie (017)
3	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4		water	water		18.0	147	Chemie (HOH)

Sequence modifications

B, A: 1 - 99 (UniProt: Q7ZCR0)

PDB	External Database	Details
Lys 7	Gln 7	engineered mutation
Val 89	Leu 89	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	21635.6
Non-Polymers*	Number of molecules	3
	Total formula weight	739.8
All*	Total formula weight	22375.4

*Water molecules are not included.