6OOT
HIV-1 Protease NL4-3 L89V, L90M Mutant in complex with darunavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NL4-3 PROTEASE | polymer | 99 | 10835.8 | 2 | UniProt (Q3HWC9) UniProt (by SIFTS) (P12497) | Human immunodeficiency virus 1 | |
| 2 | C, E (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | D (B) | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 1 | Chemie (017) PubChem (44400512) PubChem (44578485) PubChem (52949690) PubChem (23545473) PubChem (66725685) PubChem (3001874) PubChem (58330571) PubChem (89394603) PubChem (102206609) PubChem (6320435) PubChem (60170302) PubChem (125136514) PubChem (70329566) PubChem (89334570) PubChem (213039) PubChem (101897907) PubChem (102206607) PubChem (102206608) PubChem (118243427) PubChem (118243428) PubChem (118243429) PubChem (125136515) PubChem (6320436) PubChem (6320437) PubChem (129010372) PubChem (131632443) PubChem (131667685) PubChem (134694394) PubChem (137704505) PubChem (137704865) PubChem (138631483) PubChem (138631484) PubChem (138631622) PubChem (144227995) PubChem (145507139) PubChem (147231834) PubChem (156183881) PubChem (156183911) PubChem (171370671) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 127 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: Q3HWC9)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
| Val 89 | Leu 89 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21671.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 739.8 | |
| All* | Total formula weight | 22411.5 |
