6OO7
Cryo-EM structure of the C2-symmetric TRPV2/RTx complex in nanodiscs
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | TRPV2 | polymer | 786 | 88722.7 | 4 | UniProt (G1SNM3) Pfam (PF12796) Pfam (PF00520) In PDB | Oryctolagus cuniculus (Rabbit) | |
2 | A, B, C, D | resiniferatoxin | non-polymer | 628.7 | 4 | Chemie (6EU) |
Sequence modifications
A, B, C, D: 1 - 762 (UniProt: G1SNM3)
PDB | External Database | Details |
---|---|---|
Ser 470 | Phe 525 | engineered mutation |
Ala 504 | Val 559 | conflict |
Met 505 | Leu 560 | engineered mutation |
Thr 508 | Leu 563 | engineered mutation |
Glu 528 | Gln 583 | engineered mutation |
Ser 763 | - | expression tag |
Asn 764 | - | expression tag |
Leu 765 | - | expression tag |
Glu 766 | - | expression tag |
Val 767 | - | expression tag |
Leu 768 | - | expression tag |
Phe 769 | - | expression tag |
Gln 770 | - | expression tag |
Gly 771 | - | expression tag |
Pro 772 | - | expression tag |
His 773 | - | expression tag |
His 774 | - | expression tag |
His 775 | - | expression tag |
His 776 | - | expression tag |
His 777 | - | expression tag |
His 778 | - | expression tag |
Asp 779 | - | expression tag |
Tyr 780 | - | expression tag |
Lys 781 | - | expression tag |
Asp 782 | - | expression tag |
Asp 783 | - | expression tag |
Asp 784 | - | expression tag |
Asp 785 | - | expression tag |
Lys 786 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 354890.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 2514.8 | |
All* | Total formula weight | 357405.6 |