6OMU
Structure of human Bruton's Tyrosine Kinase in complex with Evobrutinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase BTK | polymer | 271 | 31598.3 | 1 | UniProt (Q06187) Pfam (PF07714) | Homo sapiens (Human) | Agammaglobulinemia tyrosine kinase, ATK, B-cell progenitor kinase, BPK, Bruton tyrosine kinase |
| 2 | B (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | C (A) | 1-[4-({[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino}methyl)piperidin-1-yl]prop-2-en-1-one | non-polymer | 429.5 | 1 | Chemie (MZJ) | |||
| 4 | D (A) | water | water | 18.0 | 428 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31598.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 465.0 | |
| All* | Total formula weight | 32063.3 |
