6OMM
Cryo-EM structure of formyl peptide receptor 2/lipoxin A4 receptor in complex with Gi
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | N-formyl peptide receptor 2 | polymer | 363 | 40329.2 | 1 | UniProt (P25090) Pfam (PF00001) In PDB | Homo sapiens (Human) | FMLP-related receptor I,FMLP-R-I,Formyl peptide receptor-like 1,HM63,Lipoxin A4 receptor,LXA4 receptor,RFP |
2 | L | Peptide agonist | polymer | 6 | 857.1 | 1 | synthetic construct | ||
3 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 353 | 40327.9 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
4 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 353 | 39021.6 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
5 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 67 | 7430.6 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
6 | E | scFv16 | polymer | 247 | 26323.3 | 1 | synthetic construct | ||
7 | R | CHOLESTEROL | non-polymer | 386.7 | 5 | Chemie (CLR) | |||
8 | R | PALMITIC ACID | non-polymer | 256.4 | 3 | Chemie (PLM) |
Sequence modifications
R: 1 - 342 (UniProt: P25090)
A: 2 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
C: 2 - 68 (UniProt: P59768)
PDB | External Database | Details |
---|---|---|
Asp -20 | - | expression tag |
Tyr -19 | - | expression tag |
Lys -18 | - | expression tag |
Asp -17 | - | expression tag |
Asp -16 | - | expression tag |
Asp -15 | - | expression tag |
Asp -14 | - | expression tag |
Val -13 | - | expression tag |
Asp -12 | - | expression tag |
Gly -11 | - | expression tag |
Ser -10 | - | expression tag |
Ala -9 | - | expression tag |
Glu -8 | - | expression tag |
Asn -7 | - | expression tag |
Leu -6 | - | expression tag |
Tyr -5 | - | expression tag |
Phe -4 | - | expression tag |
Gln -3 | - | expression tag |
Gly -2 | - | expression tag |
Ala -1 | - | expression tag |
Ser 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ala 203 | Gly 203 | engineered mutation |
Ser 326 | Ala 326 | engineered mutation |
Glu 328 | Asp 328 | engineered mutation |
PDB | External Database | Details |
---|---|---|
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
Met -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
Glu 6 | Gln 6 | engineered mutation |
Gln 130 | Glu 130 | engineered mutation |
Asp 237 | Asn 237 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gln 17 | Glu 17 | engineered mutation |
Gln 58 | Glu 58 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 154289.8 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2702.5 | |
All* | Total formula weight | 156992.3 |