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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6OMM

Cryo-EM structure of formyl peptide receptor 2/lipoxin A4 receptor in complex with Gi

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(R)		N-formyl peptide receptor 2polymer36340329.21UniProt (P25090)
Pfam (PF00001)		Homo sapiens (Human)FMLP-related receptor I,FMLP-R-I,Formyl peptide receptor-like 1,HM63,Lipoxin A4 receptor,LXA4 receptor,RFP
2B
(L)		Peptide agonistpolymer6857.11synthetic construct
3C
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-1polymer35340327.91UniProt (P63096)
Pfam (PF00503)		Homo sapiens (Human)Adenylate cyclase-inhibiting G alpha protein
4D
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer35339021.61UniProt (P62873)
Pfam (PF25391)		Homo sapiens (Human)Transducin beta chain 1
5E
(C)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer677430.61UniProt (P59768)
Pfam (PF00631)		Homo sapiens (Human)G gamma-I
6F
(E)		scFv16polymer24726323.31synthetic construct
7G, H, I, J, K
(R)		CHOLESTEROLnon-polymer386.75Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (18640088)
PubChem (1715243)
PubChem (1715244)
PubChem (45044259)
PubChem (23423981)
PubChem (49853509)
PubChem (50990013)
PubChem (52934537)
PubChem (56621683)
PubChem (191463)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (368063)
PubChem (369319)
PubChem (44654663)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (46937002)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (638019)
PubChem (59274407)
PubChem (1549081)
PubChem (1553803)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (89951918)
PubChem (90224410)
PubChem (5997)
PubChem (5283629)
PubChem (5284644)
PubChem (1551269)
PubChem (90070115)
PubChem (91298236)
PubChem (5315842)
PubChem (117965027)
PubChem (6432564)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (6419195)
PubChem (10861996)
PubChem (132837164)
PubChem (101624109)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (124225449)
PubChem (138967089)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (139566851)
PubChem (124429284)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (15939944)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (171828367)
PubChem (173516975)
PubChem (130459183)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
8L, M, N
(R)		PALMITIC ACIDnon-polymer256.43Chemie (PLM)
Sequence modifications
R: 1 - 342 (UniProt: P25090)
PDBExternal DatabaseDetails
Asp -20-expression tag
Tyr -19-expression tag
Lys -18-expression tag
Asp -17-expression tag
Asp -16-expression tag
Asp -15-expression tag
Asp -14-expression tag
Val -13-expression tag
Asp -12-expression tag
Gly -11-expression tag
Ser -10-expression tag
Ala -9-expression tag
Glu -8-expression tag
Asn -7-expression tag
Leu -6-expression tag
Tyr -5-expression tag
Phe -4-expression tag
Gln -3-expression tag
Gly -2-expression tag
Ala -1-expression tag
Ser 0-expression tag
A: 2 - 354 (UniProt: P63096)
PDBExternal DatabaseDetails
Ala 203Gly 203engineered mutation
Ser 326Ala 326engineered mutation
Glu 328Asp 328engineered mutation
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
His -12-expression tag
His -11-expression tag
His -10-expression tag
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
Met -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
Glu 6Gln 6engineered mutation
Gln 130Glu 130engineered mutation
Asp 237Asn 237engineered mutation
C: 2 - 68 (UniProt: P59768)
PDBExternal DatabaseDetails
Gln 17Glu 17engineered mutation
Gln 58Glu 58engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight154289.8
Non-Polymers*Number of molecules8
Total formula weight2702.5
All*Total formula weight156992.3
*Water molecules are not included.

253091

PDB entries from 2026-05-06

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