6OLG
Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (AA) | 60S ribosomal protein L8 | polymer | 257 | 28088.9 | 1 | UniProt (P62917) Pfam (PF00181) Pfam (PF03947) | Homo sapiens (Human) | Large ribosomal subunit protein uL2 |
| 2 | B (BA) | 40S ribosomal protein SA | polymer | 215 | 24245.7 | 1 | UniProt (P08865) Pfam (PF00318) | Homo sapiens (Human) | 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,Small ribosomal subunit protein uS2 |
| 3 | C (AB) | 60S ribosomal protein L3 | polymer | 394 | 45222.9 | 1 | UniProt (P39023) Pfam (PF00297) | Homo sapiens (Human) | HIV-1 TAR RNA-binding protein B,TARBP-B,Large ribosomal subunit protein uL3 |
| 4 | D (BB) | 40S ribosomal protein S3a | polymer | 212 | 24660.0 | 1 | UniProt (P61247) Pfam (PF01015) | Homo sapiens (Human) | Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1 |
| 5 | E (AC) | 60S ribosomal protein L4 | polymer | 363 | 41171.5 | 1 | UniProt (P36578) Pfam (PF00573) Pfam (PF14374) | Homo sapiens (Human) | 60S ribosomal protein L1,Large ribosomal subunit protein uL4 |
| 6 | F (BC) | 40S ribosomal protein S2 | polymer | 222 | 24575.0 | 1 | UniProt (P15880) Pfam (PF00333) Pfam (PF03719) | Homo sapiens (Human) | 40S ribosomal protein S4,Protein LLRep3,Small ribosomal subunit protein uS5 |
| 7 | G (A3) | 5.8S ribosomal RNA | polymer | 157 | 50449.8 | 1 | Homo sapiens (Human) | ||
| 8 | H (A4) | 5S ribosomal RNA | polymer | 119 | 38385.8 | 1 | Homo sapiens (Human) | ||
| 9 | I (AD) | 60S ribosomal protein L5 | polymer | 294 | 34091.4 | 1 | UniProt (P46777) Pfam (PF17144) Pfam (PF14204) | Homo sapiens (Human) | Large ribosomal subunit protein uL18 |
| 10 | J (AE) | 60S ribosomal protein L6 | polymer | 194 | 22262.4 | 1 | UniProt (Q02878) Pfam (PF01159) | Homo sapiens (Human) | Large ribosomal subunit protein eL6,Neoplasm-related protein C140,Tax-responsive enhancer element-binding protein 107,TaxREB107 |
| 11 | K (AF) | 60S ribosomal protein L7 | polymer | 234 | 27733.1 | 1 | UniProt (P18124) Pfam (PF00327) Pfam (PF08079) | Homo sapiens (Human) | Large ribosomal subunit protein uL30 |
| 12 | L (AG) | 60S ribosomal protein L7a | polymer | 234 | 26724.6 | 1 | UniProt (P62424) Pfam (PF01248) | Homo sapiens (Human) | Large ribosomal subunit protein eL8,PLA-X polypeptide,Surfeit locus protein 3 |
| 13 | M (AH) | 60S ribosomal protein L9 | polymer | 191 | 21770.4 | 1 | UniProt (P32969) Pfam (PF00347) | Homo sapiens (Human) | Large ribosomal subunit protein uL6 |
| 14 | N (AI) | 60S ribosomal protein L10 | polymer | 211 | 24381.8 | 1 | UniProt (P27635) Pfam (PF00252) | Homo sapiens (Human) | Laminin receptor homolog,Large ribosomal subunit protein uL16,Protein QM,Ribosomal protein L10,Tumor suppressor QM |
| 15 | O (AJ) | 60S ribosomal protein L11 | polymer | 169 | 19270.3 | 1 | UniProt (P62913) Pfam (PF00281) Pfam (PF00673) | Homo sapiens (Human) | CLL-associated antigen KW-12,Large ribosomal subunit protein uL5 |
| 16 | P (AK) | 60S acidic ribosomal protein P0 | polymer | 109 | 12505.8 | 1 | UniProt (P05388) Pfam (PF00466) | Homo sapiens (Human) | 60S ribosomal protein L10E,Large ribosomal subunit protein uL10 |
| 17 | Q (AL) | 60S ribosomal protein L13 | polymer | 205 | 23574.7 | 1 | UniProt (P26373) Pfam (PF01294) | Homo sapiens (Human) | Breast basic conserved protein 1,Large ribosomal subunit protein eL13 |
| 18 | R (AM) | 60S ribosomal protein L14 | polymer | 139 | 16220.3 | 1 | UniProt (P50914) Pfam (PF01929) | Homo sapiens (Human) | CAG-ISL 7,Large ribosomal subunit protein eL14 |
| 19 | S (AN) | 60S ribosomal protein L15 | polymer | 203 | 24076.1 | 1 | UniProt (P61313) Pfam (PF00827) | Homo sapiens (Human) | Large ribosomal subunit protein eL15 |
| 20 | T (AO) | 60S ribosomal protein L13a | polymer | 195 | 22820.4 | 1 | UniProt (P40429) Pfam (PF00572) | Homo sapiens (Human) | 23 kDa highly basic protein,Large ribosomal subunit protein uL13 |
| 21 | U (AP) | 60S ribosomal protein L17 | polymer | 153 | 17757.6 | 1 | UniProt (P18621) Pfam (PF00237) | Homo sapiens (Human) | 60S ribosomal protein L23,Large ribosomal subunit protein uL22,PD-1 |
| 22 | V (AQ) | 60S ribosomal protein L18 | polymer | 187 | 21556.5 | 1 | UniProt (Q07020) Pfam (PF17135) | Homo sapiens (Human) | Large ribosomal subunit protein eL18 |
| 23 | W (AR) | 60S ribosomal protein L19 | polymer | 181 | 21742.1 | 1 | UniProt (P84098) Pfam (PF01280) | Homo sapiens (Human) | Large ribosomal subunit protein eL19 |
| 24 | X (AS) | 60S ribosomal protein L18a | polymer | 175 | 20661.3 | 1 | UniProt (Q02543) Pfam (PF01775) | Homo sapiens (Human) | Large ribosomal subunit protein eL20 |
| 25 | Y (AT) | 60S ribosomal protein L21 | polymer | 157 | 18276.5 | 1 | UniProt (P46778) Pfam (PF01157) | Homo sapiens (Human) | Large ribosomal subunit protein eL21 |
| 26 | Z (AU) | 60S ribosomal protein L22 | polymer | 99 | 11481.2 | 1 | UniProt (P35268) Pfam (PF01776) | Homo sapiens (Human) | EBER-associated protein,EAP,Epstein-Barr virus small RNA-associated protein,Heparin-binding protein HBp15,Large ribosomal subunit protein eL22 |
| 27 | AA (AV) | 60S ribosomal protein L23 | polymer | 129 | 13828.3 | 1 | UniProt (Q9BTQ7) Pfam (PF00238) UniProt (by SIFTS) (P62829) | Homo sapiens (Human) | |
| 28 | BA (AW) | 60S ribosomal protein L24 | polymer | 121 | 14087.4 | 1 | UniProt (P83731) Pfam (PF01246) | Homo sapiens (Human) | 60S ribosomal protein L30,Large ribosomal subunit protein eL24 |
| 29 | CA (AX) | 60S ribosomal protein L23a | polymer | 117 | 13614.0 | 1 | UniProt (P62750) Pfam (PF03939) Pfam (PF00276) | Homo sapiens (Human) | Large ribosomal subunit protein uL23 |
| 30 | DA (AY) | 60S ribosomal protein L26 | polymer | 127 | 15161.9 | 1 | UniProt (P61254) Pfam (PF16906) Pfam (PF00467) | Homo sapiens (Human) | Large ribosomal subunit protein uL24 |
| 31 | EA (AZ) | 60S ribosomal protein L27 | polymer | 134 | 15647.6 | 1 | UniProt (P61353) Pfam (PF00467) Pfam (PF01777) | Homo sapiens (Human) | Large ribosomal subunit protein eL27 |
| 32 | FA (Aa) | 60S ribosomal protein L27a | polymer | 147 | 16473.3 | 1 | UniProt (P46776) Pfam (PF00828) | Homo sapiens (Human) | Large ribosomal subunit protein uL15 |
| 33 | GA (Ab) | 60S ribosomal protein L29 | polymer | 121 | 13965.8 | 1 | UniProt (P47914) Pfam (PF01779) | Homo sapiens (Human) | Cell surface heparin-binding protein HIP,Large ribosomal subunit protein eL29 |
| 34 | HA (Ac) | 60S ribosomal protein L30 | polymer | 103 | 11500.6 | 1 | UniProt (P62888) Pfam (PF01248) | Homo sapiens (Human) | Large ribosomal subunit protein eL30 |
| 35 | IA (Ad) | 60S ribosomal protein L31 | polymer | 106 | 12506.6 | 1 | UniProt (P62899) Pfam (PF01198) | Homo sapiens (Human) | Large ribosomal subunit protein eL31 |
| 36 | JA (Ae) | 60S ribosomal protein L32 | polymer | 129 | 15179.2 | 1 | UniProt (P62910) Pfam (PF01655) | Homo sapiens (Human) | Large ribosomal subunit protein eL32 |
| 37 | KA (Af) | 60S ribosomal protein L35a | polymer | 109 | 12433.5 | 1 | UniProt (P18077) Pfam (PF01247) | Homo sapiens (Human) | Cell growth-inhibiting gene 33 protein,Large ribosomal subunit protein eL33 |
| 38 | LA (Ag) | 60S ribosomal protein L34 | polymer | 114 | 12994.6 | 1 | UniProt (P49207) Pfam (PF01199) | Homo sapiens (Human) | Large ribosomal subunit protein eL34 |
| 39 | MA (Ah) | 60S ribosomal protein L35 | polymer | 122 | 14462.4 | 1 | UniProt (P42766) Pfam (PF00831) | Homo sapiens (Human) | Large ribosomal subunit protein uL29 |
| 40 | NA (Ai) | 60S ribosomal protein L36 | polymer | 97 | 11373.7 | 1 | UniProt (Q9Y3U8) Pfam (PF01158) | Homo sapiens (Human) | Large ribosomal subunit protein eL36 |
| 41 | OA (Aj) | 60S ribosomal protein L37 | polymer | 84 | 9864.6 | 1 | UniProt (P61927) Pfam (PF01907) | Homo sapiens (Human) | G1.16,Large ribosomal subunit protein eL37 |
| 42 | PA (Ak) | 60S ribosomal protein L38 | polymer | 69 | 8107.8 | 1 | UniProt (P63173) Pfam (PF01781) | Homo sapiens (Human) | Large ribosomal subunit protein eL38 |
| 43 | QA (Al) | 60S ribosomal protein L39 | polymer | 50 | 6295.6 | 1 | UniProt (P62891) Pfam (PF00832) | Homo sapiens (Human) | Large ribosomal subunit protein eL39 |
| 44 | RA (Am) | 60S ribosomal protein L40 | polymer | 50 | 5957.2 | 1 | UniProt (P62987) Pfam (PF01020) | Homo sapiens (Human) | CEP52,Ubiquitin A-52 residue ribosomal protein fusion product 1 |
| 45 | SA (An) | 60S ribosomal protein L41 | polymer | 25 | 3473.5 | 1 | UniProt (P62945) Pfam (PF05162) | Homo sapiens (Human) | HG12,Large ribosomal subunit protein eL41 |
| 46 | TA (Ao) | 60S ribosomal protein L36a | polymer | 105 | 12345.8 | 1 | UniProt (P83881) Pfam (PF00935) | Homo sapiens (Human) | 60S ribosomal protein L44,Cell growth-inhibiting gene 15 protein,Cell migration-inducing gene 6 protein,Large ribosomal subunit protein eL42 |
| 47 | UA (Ap) | 60S ribosomal protein L37a | polymer | 91 | 10168.2 | 1 | UniProt (P61513) Pfam (PF01780) | Homo sapiens (Human) | Large ribosomal subunit protein eL43 |
| 48 | VA (Aq) | 60S ribosomal protein L12 | polymer | 138 | 14942.4 | 1 | UniProt (P30050) Pfam (PF03946) Pfam (PF00298) | Homo sapiens (Human) | Large ribosomal subunit protein uL11 |
| 49 | WA (At) | 60S ribosomal protein L28 | polymer | 122 | 13991.4 | 1 | UniProt (P46779) Pfam (PF01778) | Homo sapiens (Human) | Large ribosomal subunit protein eL28 |
| 50 | XA (Au) | 60S ribosomal protein L10a | polymer | 217 | 24879.4 | 1 | UniProt (P62906) Pfam (PF00687) | Homo sapiens (Human) | CSA-19,Large ribosomal subunit protein uL1,Neural precursor cell expressed developmentally down-regulated protein 6,NEDD-6 |
| 51 | YA (A2) | 28S ribosomal RNA | polymer | 3612 | 1170164.9 | 1 | Homo sapiens (Human) | ||
| 52 | ZA (B1) | 18S ribosomal RNA | polymer | 1708 | 551108.2 | 1 | Homo sapiens (Human) | ||
| 53 | AB (BD) | 40S ribosomal protein S3 | polymer | 220 | 24357.6 | 1 | UniProt (P23396) Pfam (PF07650) Pfam (PF00189) | Homo sapiens (Human) | Small ribosomal subunit protein uS3 |
| 54 | BB (BE) | 40S ribosomal protein S4, Y isoform 1 | polymer | 257 | 28893.0 | 1 | UniProt (P22090) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) | Homo sapiens (Human) | Small ribosomal subunit protein eS4 |
| 55 | CB (BF) | 40S ribosomal protein S5 | polymer | 190 | 21424.8 | 1 | UniProt (P46782) Pfam (PF00177) | Homo sapiens (Human) | Small ribosomal subunit protein uS7 |
| 56 | DB (BG) | 40S ribosomal protein S6 | polymer | 232 | 26913.9 | 1 | UniProt (P62753) Pfam (PF01092) | Homo sapiens (Human) | Phosphoprotein NP33,Small ribosomal subunit protein eS6 |
| 57 | EB (BH) | 40S ribosomal protein S7 | polymer | 183 | 20990.5 | 1 | UniProt (P62081) Pfam (PF01251) | Homo sapiens (Human) | Small ribosomal subunit protein eS7 |
| 58 | FB (BI) | 40S ribosomal protein S8 | polymer | 207 | 24132.2 | 1 | UniProt (P62241) Pfam (PF01201) | Homo sapiens (Human) | Small ribosomal subunit protein eS8 |
| 59 | GB (BJ) | 40S ribosomal protein S9 | polymer | 179 | 21222.2 | 1 | UniProt (P46781) Pfam (PF00163) Pfam (PF01479) | Homo sapiens (Human) | Small ribosomal subunit protein uS4 |
| 60 | HB (BK) | 40S ribosomal protein S10 | polymer | 98 | 11774.0 | 1 | UniProt (P46783) Pfam (PF03501) | Homo sapiens (Human) | Small ribosomal subunit protein eS10 |
| 61 | IB (BL) | 40S ribosomal protein S11 | polymer | 153 | 17910.2 | 1 | UniProt (P62280) Pfam (PF16205) Pfam (PF00366) | Homo sapiens (Human) | Small ribosomal subunit protein uS17 |
| 62 | JB (BM) | 40S ribosomal protein S12 | polymer | 120 | 13393.7 | 1 | UniProt (P25398) Pfam (PF01248) | Homo sapiens (Human) | Small ribosomal subunit protein eS12 |
| 63 | KB (BN) | 40S ribosomal protein S13 | polymer | 149 | 17057.1 | 1 | UniProt (P62277) Pfam (PF08069) Pfam (PF00312) | Homo sapiens (Human) | Small ribosomal subunit protein uS15 |
| 64 | LB (BO) | 40S ribosomal protein S14 | polymer | 136 | 14544.7 | 1 | UniProt (P62263) Pfam (PF00411) | Homo sapiens (Human) | Small ribosomal subunit protein uS11 |
| 65 | MB (BP) | 40S ribosomal protein S15 | polymer | 120 | 14273.9 | 1 | UniProt (P62841) Pfam (PF00203) | Homo sapiens (Human) | RIG protein,Small ribosomal subunit protein uS19 |
| 66 | NB (BQ) | 40S ribosomal protein S16 | polymer | 139 | 15765.5 | 1 | UniProt (P62249) Pfam (PF00380) | Homo sapiens (Human) | Small ribosomal subunit protein uS9 |
| 67 | OB (BR) | 40S ribosomal protein S17 | polymer | 125 | 14447.8 | 1 | UniProt (P08708) Pfam (PF00833) | Homo sapiens (Human) | Small ribosomal subunit protein eS17 |
| 68 | PB (BS) | 40S ribosomal protein S18 | polymer | 139 | 16383.1 | 1 | UniProt (P62269) Pfam (PF00416) | Homo sapiens (Human) | Ke-3,Ke3,Small ribosomal subunit protein uS13 |
| 69 | QB (BT) | 40S ribosomal protein S19 | polymer | 143 | 15822.2 | 1 | UniProt (P39019) Pfam (PF01090) | Homo sapiens (Human) | Small ribosomal subunit protein eS19 |
| 70 | RB (BU) | 40S ribosomal protein S20 | polymer | 97 | 11029.1 | 1 | UniProt (P60866) Pfam (PF00338) | Homo sapiens (Human) | Small ribosomal subunit protein uS10 |
| 71 | SB (BV) | 40S ribosomal protein S21 | polymer | 81 | 8863.1 | 1 | UniProt (P63220) Pfam (PF01249) | Homo sapiens (Human) | Small ribosomal subunit protein eS21 |
| 72 | TB (BW) | 40S ribosomal protein S15a | polymer | 129 | 14734.4 | 1 | UniProt (P62244) Pfam (PF00410) | Homo sapiens (Human) | Small ribosomal subunit protein uS8 |
| 73 | UB (BX) | 40S ribosomal protein S23 | polymer | 139 | 15372.1 | 1 | UniProt (P62266) Pfam (PF00164) | Homo sapiens (Human) | Small ribosomal subunit protein uS12 |
| 74 | VB (BY) | 40S ribosomal protein S24 | polymer | 125 | 14489.2 | 1 | UniProt (P62847) Pfam (PF01282) | Homo sapiens (Human) | Small ribosomal subunit protein eS24 |
| 75 | WB (BZ) | 40S ribosomal protein S25 | polymer | 86 | 9801.7 | 1 | UniProt (P62851) Pfam (PF03297) | Homo sapiens (Human) | Small ribosomal subunit protein eS25 |
| 76 | XB (Ba) | 40S ribosomal protein S26 | polymer | 97 | 11087.1 | 1 | UniProt (P62854) Pfam (PF01283) | Homo sapiens (Human) | Small ribosomal subunit protein eS26 |
| 77 | YB (Bb) | 40S ribosomal protein S27 | polymer | 80 | 9000.6 | 1 | UniProt (P42677) Pfam (PF01667) | Homo sapiens (Human) | Metallopan-stimulin 1,MPS-1,Small ribosomal subunit protein eS27 |
| 78 | ZB (Bc) | 40S ribosomal protein S28 | polymer | 62 | 7007.1 | 1 | UniProt (P62857) Pfam (PF01200) | Homo sapiens (Human) | Small ribosomal subunit protein eS28 |
| 79 | AC (Bd) | 40S ribosomal protein S29 | polymer | 51 | 6121.2 | 1 | UniProt (P62273) Pfam (PF00253) | Homo sapiens (Human) | Small ribosomal subunit protein uS14 |
| 80 | BC (Be) | 40S ribosomal protein S30 | polymer | 55 | 6239.4 | 1 | UniProt (E9PR30) Pfam (PF04758) UniProt (by SIFTS) (P62861) | Homo sapiens (Human) | |
| 81 | CC (Bf) | 40S ribosomal protein S27a | polymer | 73 | 8645.3 | 1 | UniProt (P62979) Pfam (PF01599) | Homo sapiens (Human) | Ubiquitin carboxyl extension protein 80 |
| 82 | DC (Bg) | Receptor of activated protein C kinase 1 | polymer | 314 | 34726.2 | 1 | UniProt (P63244) Pfam (PF00400) | Homo sapiens (Human) | Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1 |
| 83 | EC (Bv) | tRNA | polymer | 76 | 24485.5 | 1 | Homo sapiens (Human) | ||
| 84 | FC (Bx) | mRNA | polymer | 16 | 4853.7 | 1 | Homo sapiens (Human) | ||
| 85 | GC (A) | Cadherin-1 | polymer | 39 | 4040.0 | 1 | UniProt (P12830) | Homo sapiens (Human) | CAM 120/80,Epithelial cadherin,E-cadherin,Uvomorulin |
| 86 | AD, AE, AF, AG, AH... (Aa, A2, B1, Bv, Ae...) | MAGNESIUM ION | non-polymer | 24.3 | 326 | Chemie (MG) | |||
| 87 | CD, DD, ED, XO, YO (Aj, Ao, Ap, Ba, Bd) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 88 | XL (A2) | N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide | non-polymer | 433.9 | 1 | Chemie (MVM) |
Sequence modifications
A: 1 - 39 (UniProt: P12830)
| PDB | External Database | Details |
|---|---|---|
| Ala 6 | - | insertion |
| Glu 10 | Val 701 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 85 |
| Total formula weight | 3198035.9 | |
| Non-Polymers* | Number of molecules | 332 |
| Total formula weight | 8684.4 | |
| All* | Total formula weight | 3206720.3 |
