6OKO

Crystal structure of mRIPK3 complexed with N-(3-fluoro-4-{1H-pyrrolo[2,3-b]pyridin-4-yloxy}phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Receptor-interacting serine/threonine-protein kinase 3	polymer	325	36213.3	2	UniProt (Q9QZL0) Pfam (PF00069) In PDB	Mus musculus (Mouse)	RIP-like protein kinase 3, Receptor-interacting protein 3, mRIP3
2	A, B	1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide	non-polymer		458.4	2	Chemie (1FN)
3		water	water		18.0	202	Chemie (HOH)

Sequence modifications

A, B: 1 - 313 (UniProt: Q9QZL0)

PDB	External Database	Details
Ala 111	Cys 111	conflict
Asp 136	Asn 136	conflict
Lys 198	Asp 198	conflict
Leu 314	-	expression tag
Glu 315	-	expression tag
His 316	-	expression tag
His 317	-	expression tag
His 318	-	expression tag
His 319	-	expression tag
His 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72426.7
Non-Polymers*	Number of molecules	2
	Total formula weight	916.8
All*	Total formula weight	73343.5

*Water molecules are not included.