6OJU
Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-D-glutamic acid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A, C, D | Thymidylate synthase,Thymidylate synthase | polymer | 290 | 33189.1 | 4 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens (Human) | TSase,TSase |
2 | B, A, C, D | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 4 | Chemie (UMP) | |||
3 | B, A, C, D | N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}-D-glutamic acid | non-polymer | 413.4 | 4 | Chemie (D96) | |||
4 | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 132756.3 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2886.3 | |
All* | Total formula weight | 135642.5 |