6OJU

Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-D-glutamic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (B, A, C, D)	Thymidylate synthase,Thymidylate synthase	polymer	290	33189.1	4	UniProt (P04818) Pfam (PF00303)	Homo sapiens (Human)	TSase,TSase
2	E, G, I, K (B, A, C, D)	2'-DEOXYURIDINE 5'-MONOPHOSPHATE	non-polymer		308.2	4	Chemie (UMP)
3	F, H, J, L (B, A, C, D)	N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}-D-glutamic acid	non-polymer		413.4	4	Chemie (D96)
4	M, N, O, P (B, A, C, D)	water	water		18.0	34	Chemie (HOH)

Sequence modifications

B, A, C, D: 1 - 6 (UniProt: P04818)
B, A, C, D: 30 - 313 (UniProt: P04818)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	132756.3
Non-Polymers*	Number of molecules	8
	Total formula weight	2886.3
All*	Total formula weight	135642.5

*Water molecules are not included.