6OIK
Muscarinic acetylcholine receptor 2-Go complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Muscarinic acetylcholine receptor M2,Muscarinic acetylcholine receptor M2 | polymer | 353 | 39729.9 | 1 | UniProt (P08172) Pfam (PF00001) | Homo sapiens (Human) | |
| 2 | B (A) | Guanine nucleotide-binding protein G(o) subunit alpha | polymer | 354 | 40104.6 | 1 | UniProt (P09471) Pfam (PF00503) | Homo sapiens (Human) | |
| 3 | C (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37728.2 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 5 | E (H) | Antibody fragment | polymer | 256 | 27340.5 | 1 | Mus musculus (Mouse) | ||
| 6 | F (R) | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium | non-polymer | 197.3 | 1 | Chemie (IXO) | |||
| 7 | G (R) | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide | non-polymer | 437.9 | 1 | Chemie (2CU) |
Sequence modifications
R: 3 - 359 (UniProt: P08172)
R: 360 - 466 (UniProt: P08172)
A: 1 - 354 (UniProt: P09471)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Asp -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Lys -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Asp 1 | - | expression tag |
| Asp 2 | - | expression tag |
| Ala 3 | Asn 3 | engineered mutation |
| Asp 6 | Asn 6 | engineered mutation |
| Asp 9 | Asn 9 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Pro 467 | - | expression tag |
| Ala 468 | - | expression tag |
| Gly 469 | - | expression tag |
| Leu 470 | - | expression tag |
| Glu 471 | - | expression tag |
| Val 472 | - | expression tag |
| Leu 473 | - | expression tag |
| Phe 474 | - | expression tag |
| Gln 475 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 9 | Glu 9 | engineered mutation |
| Lys 10 | Arg 10 | engineered mutation |
| Val 13 | Leu 13 | engineered mutation |
| Met 18 | Ala 18 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 152764.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 635.2 | |
| All* | Total formula weight | 153399.4 |
