6OHW

Structural basis for human coronavirus attachment to sialic acid receptors. Apo-HCoV-OC43 S

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Spike surface glycoprotein	polymer	1322	146438.3	3	UniProt (Q696P8) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601)	Human coronavirus OC43 (HCoV-OC43)
2	AA, D, E, F, G... (a, D, E, F, G...)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	15	In PDB GlyTouCan (G15407YE)
3	BA, CA, EA, FA, H... (b, c, e, f, H...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	12	In PDB GlyTouCan (G42666HT)
4	DA, J, T (d, J, T)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	3	In PDB GlyTouCan (G81315DD)
5	HA, IA, JA, KA, LA... (A, B, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	15	Chemie (NAG)
6	WA, XA, YA (A, B, C)	water	water		18.0	186	Chemie (HOH)

Sequence modifications

A, B, C: 14 - 1273 (UniProt: Q696P8)

PDB	External Database	Details
Met -9	-	initiating methionine
Pro -8	-	expression tag
Met -7	-	expression tag
Gly -6	-	expression tag
Ser -5	-	expression tag
Leu -4	-	expression tag
Gln -3	-	expression tag
Pro -2	-	expression tag
Leu -1	-	expression tag
Ala 0	-	expression tag
Thr 1	-	expression tag
Leu 2	-	expression tag
Tyr 3	-	expression tag
Leu 4	-	expression tag
Leu 5	-	expression tag
Gly 6	-	expression tag
Met 7	-	expression tag
Leu 8	-	expression tag
Val 9	-	expression tag
Ala 10	-	expression tag
Ser 11	-	expression tag
Val 12	-	expression tag
Leu 13	-	expression tag
Gly 764	Arg 754	engineered mutation
Gly 765	Arg 755	engineered mutation
Gly 767	Arg 757	engineered mutation
Leu 1274	-	expression tag
Ile 1275	-	expression tag
Lys 1276	-	expression tag
Arg 1277	-	expression tag
Met 1278	-	expression tag
Lys 1279	-	expression tag
Gln 1280	-	expression tag
Ile 1281	-	expression tag
Glu 1282	-	expression tag
Asp 1283	-	expression tag
Lys 1284	-	expression tag
Ile 1285	-	expression tag
Glu 1286	-	expression tag
Glu 1287	-	expression tag
Ile 1288	-	expression tag
Glu 1289	-	expression tag
Ser 1290	-	expression tag
Lys 1291	-	expression tag
Gln 1292	-	expression tag
Lys 1293	-	expression tag
Lys 1294	-	expression tag
Ile 1295	-	expression tag
Glu 1296	-	expression tag
Asn 1297	-	expression tag
Glu 1298	-	expression tag
Ile 1299	-	expression tag
Ala 1300	-	expression tag
Arg 1301	-	expression tag
Ile 1302	-	expression tag
Lys 1303	-	expression tag
Lys 1304	-	expression tag
Ile 1305	-	expression tag
Lys 1306	-	expression tag
Leu 1307	-	expression tag
Val 1308	-	expression tag
Pro 1309	-	expression tag
Arg 1310	-	expression tag
Gly 1311	-	expression tag
Ser 1312	-	expression tag
Leu 1313	-	expression tag
Glu 1314	-	expression tag
Trp 1315	-	expression tag
Ser 1316	-	expression tag
His 1317	-	expression tag
Pro 1318	-	expression tag
Gln 1319	-	expression tag
Phe 1320	-	expression tag
Glu 1321	-	expression tag
Lys 1322	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	439314.9
Branched	Number of molecules	30
	Total formula weight	16137.0
Non-Polymers*	Number of molecules	15
	Total formula weight	3318.1
All*	Total formula weight	458770.0

*Water molecules are not included.