6OE4
Prefusion RSV F monomer bound by neutralizing antibody CR9501
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, D) | Fusion glycoprotein F0 | polymer | 521 | 57943.5 | 2 | UniProt (P03420) Pfam (PF00523) | Human respiratory syncytial virus A (strain A2) | Protein F, Prefusion RSV F |
| 2 | C, F (C, F) | CR9501 Fab Light Chain | polymer | 214 | 23557.1 | 2 | Homo sapiens | ||
| 3 | D, E (B, E) | CR9501 Fab Heavy Chain | polymer | 230 | 24367.3 | 2 | Homo sapiens | ||
| 4 | G, H, I, J, K (D, C, F) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) |
Sequence modifications
A, D: 1 - 513 (UniProt: P03420)
| PDB | External Database | Details |
|---|---|---|
| Ala 102 | Pro 102 | conflict |
| Cys 155 | Ser 155 | engineered mutation |
| Phe 190 | Ser 190 | engineered mutation |
| Leu 207 | Val 207 | engineered mutation |
| Cys 290 | Ser 290 | engineered mutation |
| Val 379 | Ile 379 | conflict |
| Val 447 | Met 447 | conflict |
| Gly 514 | - | expression tag |
| Ser 515 | - | expression tag |
| Leu 516 | - | expression tag |
| Glu 517 | - | expression tag |
| Val 518 | - | expression tag |
| Leu 519 | - | expression tag |
| Phe 520 | - | expression tag |
| Gln 521 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 211735.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 310.3 | |
| All* | Total formula weight | 212046.0 |
