6OCZ
Crystal Structure of Mycobacterium tuberculosis Proteasome in Complex with Phenylimidazole-based Inhibitor A86
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Proteasome subunit alpha | polymer | 240 | 25972.0 | 14 | UniProt (P9WHU1) Pfam (PF00227) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | 20S proteasome alpha subunit, Proteasome core protein PrcA |
| 2 | AA, BA, H, I, J... (H, I, J, K, L...) | Proteasome subunit beta | polymer | 234 | 24445.4 | 14 | UniProt (P9WHT9) Pfam (PF00227) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | 20S proteasome beta subunit, Proteasome core protein PrcB |
| 3 | BB, CA, CB, DA, DB... (O, A, P, B, Q...) | DIMETHYLFORMAMIDE | non-polymer | 73.1 | 20 | Chemie (DMF) | |||
| 4 | KA, KB, MA, MB, OB... (H, V, I, W, X...) | N-{(2S)-1-({(2S)-1-[(2,4-difluorobenzyl)amino]-1-oxopropan-2-yl}amino)-1,4-dioxo-4-[(2R)-2-phenylpyrrolidin-1-yl]butan-2-yl}-5-methyl-1,2-oxazole-3-carboxamide (non-preferred name) | non-polymer | 567.6 | 14 | Chemie (M6Y) | |||
| 5 | AB, LA, LB, NA, NB... (N, H, V, I, W...) | CITRIC ACID | non-polymer | 192.1 | 14 | Chemie (CIT) | |||
| 6 | AC, BC, CC, DC, EC... (C, D, E, F, G...) | water | water | 18.0 | 854 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, O, P, Q, R, S, T, U: 10 - 248 (UniProt: P9WHU1)
| PDB | External Database | Details |
|---|---|---|
| Met 9 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 705843.0 | |
| Non-Polymers* | Number of molecules | 48 |
| Total formula weight | 12097.8 | |
| All* | Total formula weight | 717940.8 |
