6OCU
HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 29
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | polymer | 1044 | 119633.0 | 1 | UniProt (O00329) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (Human) | PtdIns-3-kinase subunit delta,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta,p110delta |
| 2 | B | Phosphatidylinositol 3-kinase regulatory subunit alpha | polymer | 188 | 22968.0 | 1 | UniProt (P23727) Pfam (PF16454) In PDB | Bos taurus (Bovine) | PtdIns-3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PtdIns-3-kinase regulatory subunit p85-alpha |
| 3 | A | 5-{(3R)-3-methyl-4-[(1R,2R)-2-methylcyclopropane-1-carbonyl]piperazin-1-yl}-3-(1-methyl-1H-pyrazol-4-yl)pyrazine-2-carbonitrile | non-polymer | 365.4 | 1 | Chemie (M5D) |
Sequence modifications
B: 431 - 600 (UniProt: P23727)
| PDB | External Database | Details |
|---|---|---|
| Met 430 | - | initiating methionine |
| Ser 601 | - | expression tag |
| Arg 602 | - | expression tag |
| Ala 603 | - | expression tag |
| Cys 604 | - | expression tag |
| Ser 605 | - | expression tag |
| Leu 606 | - | expression tag |
| Glu 607 | - | expression tag |
| Ala 608 | - | expression tag |
| Cys 609 | - | expression tag |
| Gly 610 | - | expression tag |
| Thr 611 | - | expression tag |
| Lys 612 | - | expression tag |
| Leu 613 | - | expression tag |
| Val 614 | - | expression tag |
| Glu 615 | - | expression tag |
| Lys 616 | - | expression tag |
| Tyr 617 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 142601.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 365.4 | |
| All* | Total formula weight | 142966.5 |
