6OC1
Crystal structure of human DHODH with TAK-632
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dihydroorotate dehydrogenase (quinone), mitochondrial | polymer | 369 | 40125.9 | 1 | UniProt (Q02127) Pfam (PF01180) In PDB | Homo sapiens (Human) | DHOdehase,Dihydroorotate oxidase |
| 2 | A | OROTIC ACID | non-polymer | 156.1 | 1 | Chemie (ORO) | |||
| 3 | A | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 4 | A | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 5 | A | N-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide | non-polymer | 554.5 | 1 | Chemie (1SU) | |||
| 6 | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A: 29 - 395 (UniProt: Q02127)
| PDB | External Database | Details |
|---|---|---|
| His 27 | - | expression tag |
| Met 28 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40125.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1261.9 | |
| All* | Total formula weight | 41387.8 |
