6O9G
Open state GluA2 in complex with STZ and blocked by AgTx-636, after micelle signal subtraction
Replaces: 6DM2Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit | polymer | 1031 | 115178.5 | 4 | UniProt (P19491) UniProt (Q9Y698) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00822) In PDB | Rattus norvegicus (Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,Neuronal voltage-gated calcium channel gamma-2 subunit,Transmembrane AMPAR regulatory protein gamma-2,TARP gamma-2 |
2 | A, B, C, D | GLUTAMIC ACID | non-polymer | 147.1 | 4 | Chemie (GLU) | |||
3 | A, B, C, D | CYCLOTHIAZIDE | non-polymer | 389.9 | 4 | Chemie (CYZ) | |||
4 | D | N~1~-{5-[(3-{[3-(L-arginylamino)propyl]amino}propyl)amino]pentyl}-N~2~-[(2,4-dihydroxyphenyl)acetyl]-L-aspartamide | non-polymer | 636.8 | 1 | Chemie (LU7) |
Sequence modifications
A, B, C, D: 10 - 998 (UniProt: P19491)
A, B, C, D: 1001 - 1207 (UniProt: Q9Y698)
PDB | External Database | Details |
---|---|---|
Glu 241 | Asn 256 | conflict |
Leu 382 | Val 397 | conflict |
- | Leu 399 | deletion |
- | Thr 400 | deletion |
- | Glu 401 | deletion |
- | Leu 402 | deletion |
- | Pro 403 | deletion |
- | Ser 404 | deletion |
Glu 384 | Gly 405 | conflict |
Asp 385 | Asn 406 | conflict |
Gln 392 | Asn 413 | conflict |
Gly 999 | - | linker |
Thr 1000 | - | linker |
PDB | External Database | Details |
---|---|---|
Asp 1047 | Asn 48 | conflict |
Thr 1208 | - | expression tag |
Gly 1209 | - | expression tag |
Gly 1210 | - | expression tag |
Ala 1211 | - | expression tag |
Glu 1212 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 460714.1 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 2784.8 | |
All* | Total formula weight | 463498.9 |