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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6O96

Dot1L bound to the H2BK120 Ubiquitinated nucleosome

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, E
(A, E)		Histone H3.2polymer13515303.92UniProt (P84233)
Pfam (PF00125)		Xenopus laevis (African clawed frog)
2B, F
(B, F)		Histone H4polymer10311394.42UniProt (P62799)
Pfam (PF15511)		Xenopus laevis (African clawed frog)
3C, G
(C, G)		Histone H2Apolymer13014109.42UniProt (Q6AZJ8)
Pfam (PF00125)
Pfam (PF16211)
UniProt (by SIFTS) (P06897)		Xenopus laevis (African clawed frog)
4D, H
(D, H)		Histone H2B 1.1polymer12313629.92UniProt (P02281)
Pfam (PF00125)		Xenopus laevis (African clawed frog)H2B1.1
5I
(I)		DNA (146-MER)polymer14644824.61synthetic construct
6J
(J)		DNA (146-MER)polymer14645304.91synthetic construct
7K
(K)		Histone-lysine N-methyltransferase, H3 lysine-79 specificpolymer33138245.41UniProt (Q8TEK3)
Pfam (PF08123)		Homo sapiens (Human)DOT1-like protein,Histone H3-K79 methyltransferase,H3-K79-HMTase,Lysine N-methyltransferase 4
8L
(L)		Polyubiquitin-Bpolymer768622.91UniProt (J3QS39)
Pfam (PF00240)
UniProt (by SIFTS) (P0CG47)		Homo sapiens (Human)
9M
(K)		S-ADENOSYL-L-HOMOCYSTEINEnon-polymer384.41Chemie (SAH)
PubChem (16760024)
PubChem (193)
PubChem (13792)
PubChem (177678424)
PubChem (189149)
PubChem (439155)
PubChem (25210495)
PubChem (21125603)
PubChem (44361184)
PubChem (25203782)
PubChem (46936206)
PubChem (50989525)
PubChem (51380914)
PubChem (52224398)
PubChem (57544532)
PubChem (52224400)
PubChem (59046843)
PubChem (59170628)
PubChem (59576228)
PubChem (66805708)
PubChem (5284331)
PubChem (70689219)
PubChem (70702054)
PubChem (70832431)
PubChem (71170554)
PubChem (13231890)
PubChem (6419189)
PubChem (118374891)
PubChem (118560068)
PubChem (126969526)
PubChem (129105892)
PubChem (164157219)
PubChem (143518505)
PubChem (154578335)
PubChem (163054214)
PubChem (163335525)
Sequence modifications
A, E: 1 - 135 (UniProt: P84233)
PDBExternal DatabaseDetails
Ala 102Gly 103engineered mutation
D, H: 4 - 125 (UniProt: P02281)
PDBExternal DatabaseDetails
Met 3-expression tag
Thr 32Ser 33engineered mutation
Cys 120Lys 121engineered mutation
L: 1 - 76 (UniProt: J3QS39)
PDBExternal DatabaseDetails
Cys 76Gly 76engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains12
Total formula weight245873.1
Non-Polymers*Number of molecules1
Total formula weight384.4
All*Total formula weight246257.6
*Water molecules are not included.

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PDB entries from 2026-04-01

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