6O8U
Crystal structure of IRAK4 in complex with compound 23
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Interleukin-1 receptor-associated kinase 4 | polymer | 305 | 34221.5 | 4 | UniProt (Q9NWZ3) Pfam (PF07714) In PDB | Homo sapiens (Human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
2 | A, B, C, D | N-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | non-polymer | 393.4 | 4 | Chemie (LS7) | |||
3 | A, B, C, D | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
5 | water | water | 18.0 | 454 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 160 - 460 (UniProt: Q9NWZ3)
PDB | External Database | Details |
---|---|---|
Ser 159 | - | expression tag |
Gly 461 | - | expression tag |
Asn 462 | - | expression tag |
Ser 463 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 136886.1 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 2146.2 | |
All* | Total formula weight | 139032.3 |