6O8U
Crystal structure of IRAK4 in complex with compound 23
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Interleukin-1 receptor-associated kinase 4 | polymer | 305 | 34221.5 | 4 | UniProt (Q9NWZ3) Pfam (PF07714) | Homo sapiens (Human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
| 2 | E, H, J, L (A, B, C, D) | N-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | non-polymer | 393.4 | 4 | Chemie (LS7) | |||
| 3 | F, I, K, M, N (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | G (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 454 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 160 - 460 (UniProt: Q9NWZ3)
| PDB | External Database | Details |
|---|---|---|
| Ser 159 | - | expression tag |
| Gly 461 | - | expression tag |
| Asn 462 | - | expression tag |
| Ser 463 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 136886.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2146.2 | |
| All* | Total formula weight | 139032.3 |
