6O4L
Structure of ALDH7A1 mutant E399D complexed with NAD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Alpha-aminoadipic semialdehyde dehydrogenase | polymer | 513 | 55606.3 | 4 | UniProt (P49419) Pfam (PF00171) | Homo sapiens (Human) | Alpha-AASA dehydrogenase,Aldehyde dehydrogenase family 7 member A1,Antiquitin-1,Betaine aldehyde dehydrogenase,Delta1-piperideine-6-carboxylate dehydrogenase,P6c dehydrogenase,ALDH7A1 |
| 2 | E, F, I, M (A, B, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 3 | G, J (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | H, K, L, N (A, B, C, D) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 4 | Chemie (NAD) | |||
| 5 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 757 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 511 (UniProt: P49419)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| Asp 399 | Glu 427 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 222425.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2972.9 | |
| All* | Total formula weight | 225398.2 |
