6O2P
Complex of ivacaftor with cystic fibrosis transmembrane conductance regulator (CFTR)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cystic fibrosis transmembrane conductance regulator | polymer | 1489 | 169352.6 | 1 | UniProt (P13569) Pfam (PF00664) Pfam (PF00005) Pfam (PF14396) In PDB | Homo sapiens (Human) | CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | B | Unknown Peptide | polymer | 17 | 1464.8 | 1 | Homo sapiens | ||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | A | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | A | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 6 | Chemie (POV) | |||
| 6 | A | Digitonin | non-polymer | 1229.3 | 1 | Chemie (AJP) | |||
| 7 | A | N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide | non-polymer | 392.5 | 1 | Chemie (VX7) |
Sequence modifications
A: 1 - 1480 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| Gln 1371 | Glu 1371 | engineered mutation |
| Ser 1481 | - | expression tag |
| Asn 1482 | - | expression tag |
| Ser 1483 | - | expression tag |
| Leu 1484 | - | expression tag |
| Glu 1485 | - | expression tag |
| Val 1486 | - | expression tag |
| Leu 1487 | - | expression tag |
| Phe 1488 | - | expression tag |
| Gln 1489 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 170817.4 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 7245.2 | |
| All* | Total formula weight | 178062.6 |
