6O0V
Crystal structure of the TIR domain G601P mutant from human SARM1, crystal form 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Sterile alpha and TIR motif-containing protein 1 | polymer | 144 | 16373.8 | 4 | UniProt (Q6SZW1) Pfam (PF13676) | Homo sapiens (Human) | Sterile alpha and Armadillo repeat protein,Sterile alpha motif domain-containing protein 2,SAM domain-containing protein 2,Tir-1 homolog |
| 2 | E, F, H (A, B, D) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 3 | G (C) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 4 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 228 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 560 - 700 (UniProt: Q6SZW1)
| PDB | External Database | Details |
|---|---|---|
| Ser 557 | - | expression tag |
| Asn 558 | - | expression tag |
| Ala 559 | - | expression tag |
| Pro 601 | Gly 601 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 65495.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 301.6 | |
| All* | Total formula weight | 65796.7 |
