6O0S

Crystal structure of the tandem SAM domains from human SARM1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Sterile alpha and TIR motif-containing protein 1	polymer	177	20296.8	8	UniProt (Q6SZW1) Pfam (PF07647) In PDB	Homo sapiens (Human)	Sterile alpha and Armadillo repeat protein,Sterile alpha motif domain-containing protein 2,SAM domain-containing protein 2,Tir-1 homolog

Sequence modifications

A, B, C, D, E, F, G, H: 409 - 561 (UniProt: Q6SZW1)

PDB	External Database	Details
Met 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag
His 390	-	expression tag
His 391	-	expression tag
Ser 392	-	expression tag
Ser 393	-	expression tag
Gly 394	-	expression tag
Val 395	-	expression tag
Asp 396	-	expression tag
Leu 397	-	expression tag
Gly 398	-	expression tag
Thr 399	-	expression tag
Glu 400	-	expression tag
Asn 401	-	expression tag
Leu 402	-	expression tag
Tyr 403	-	expression tag
Phe 404	-	expression tag
Gln 405	-	expression tag
Ser 406	-	expression tag
Asn 407	-	expression tag
Ala 408	-	expression tag
Phe 473	Leu 473	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	162374.2
All*	Total formula weight	162374.2

*Water molecules are not included.