6O0L
crystal structure of BCL-2 G101V mutation with venetoclax
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2 | polymer | 166 | 19399.6 | 2 | UniProt (P10415) UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) In PDB | Homo sapiens (Human) | Bcl2-L-1,Apoptosis regulator Bcl-X |
2 | A, C | 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide | non-polymer | 868.4 | 2 | Chemie (LBM) | |||
3 | A, C | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
4 | A, C | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
5 | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 75 (UniProt: P10415)
A, C: 76 - 91 (UniProt: Q07817)
A, C: 92 - 207 (UniProt: P10415)
A, C: 76 - 91 (UniProt: Q07817)
A, C: 92 - 207 (UniProt: P10415)
PDB | External Database | Details |
---|---|---|
Val 101 | Gly 101 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 38799.3 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2232.3 | |
All* | Total formula weight | 41031.5 |