6NZU

Structure of the human frataxin-bound iron-sulfur cluster assembly complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, E)	Cysteine desulfurase, mitochondrial	polymer	403	44850.4	2	UniProt (Q9Y697) Pfam (PF00266)	Homo sapiens (Human)
2	B, F (B, F)	LYR motif-containing protein 4	polymer	92	10850.6	2	UniProt (Q9HD34) Pfam (PF05347)	Homo sapiens (Human)
3	C, G (C, G)	Acyl carrier protein	polymer	74	8251.1	2	UniProt (A0A437HBF4)	Escherichia coli	ACP
4	D, H (D, H)	Iron-sulfur cluster assembly enzyme ISCU, mitochondrial	polymer	124	13412.6	2	UniProt (Q9H1K1) Pfam (PF01592)	Homo sapiens (Human)	NifU-like N-terminal domain-containing protein, NifU-like protein
5	I, J (I, J)	Frataxin, mitochondrial	polymer	132	14501.0	2	UniProt (Q16595) Pfam (PF01491)	Homo sapiens (Human)	Friedreich ataxia protein, Fxn
6	K, N (A, E)	PYRIDOXAL-5'-PHOSPHATE	non-polymer		247.1	2	Chemie (PLP)
7	L, O (C, G)	S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate	non-polymer		540.7	2	Chemie (8Q1)
8	M, P (D, H)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

A, E: 56 - 457 (UniProt: Q9Y697)

PDB	External Database	Details
Met 55	-	initiating methionine

B, F: 1 - 91 (UniProt: Q9HD34)

PDB	External Database	Details
Ser 0	-	expression tag
Ala 11	Ser 11	conflict

D, H: 35 - 157 (UniProt: Q9H1K1)

PDB	External Database	Details
Met 34	-	initiating methionine

I, J: 81 - 210 (UniProt: Q16595)

PDB	External Database	Details
Ser 79	-	expression tag
Met 80	-	expression tag

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.