6NZM
Brutons tyrosine kinase in complex with compound 50.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, D) | Tyrosine-protein kinase BTK | polymer | 280 | 32413.1 | 2 | UniProt (Q06187) Pfam (PF07714) | Homo sapiens (Human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
| 2 | C, E (A, D) | N-[2-fluoro-6-(pyrrolidin-1-yl)phenyl]-N'-{3-[(2R)-1-(2-hydroxyethyl)-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-2-yl]phenyl}urea | non-polymer | 544.6 | 2 | Chemie (L9S) | |||
| 3 | D, F (A, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | G, H (A, D) | water | water | 18.0 | 497 | Chemie (HOH) |
Sequence modifications
A, D: 382 - 659 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Gly 380 | - | expression tag |
| Ser 381 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64826.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1213.4 | |
| All* | Total formula weight | 66039.7 |
