6NY0
Crystal structure of trimethoprim-resistant type II dihydrofolate reductase in complex with a bisbenzimidazole inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dihydrofolate reductase type 2 | polymer | 61 | 6634.4 | 1 | UniProt (P00383) Pfam (PF06442) In PDB | Escherichia coli | Dihydrofolate reductase type II |
2 | A | 2-(4-{3-[4-(6-carboxy-1H-benzimidazol-2-yl)phenoxy]-2-hydroxypropoxy}phenyl)-1H-benzimidazole-5-carboxylic acid | non-polymer | 564.5 | 1 | Chemie (LBA) | |||
3 | A | (4R)-2-METHYLPENTANE-2,4-DIOL | non-polymer | 118.2 | 2 | Chemie (MRD) | |||
4 | A | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
5 | water | water | 18.0 | 64 | Chemie (HOH) |
Sequence modifications
A: 18 - 78 (UniProt: P00383)
PDB | External Database | Details |
---|---|---|
Asp 21 | Asn 21 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 6634.4 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 990.8 | |
All* | Total formula weight | 7625.2 |