6NXZ
Crystal structure of trimethoprim-resistant type II dihydrofolate reductase in complex with a bisbenzimidazole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydrofolate reductase type 2 | polymer | 62 | 6733.5 | 1 | UniProt (P00383) Pfam (PF06442) | Escherichia coli | Dihydrofolate reductase type II |
| 2 | B (A) | 2-[4-[(2~{R})-4-[4-(6-carboxy-1~{H}-benzimidazol-2-yl)phenoxy]-2-oxidanyl-butoxy]phenyl]-1~{H}-benzimidazole-5-carboxylic acid | non-polymer | 578.6 | 1 | Chemie (D49) | |||
| 3 | C, D (A) | (4R)-2-METHYLPENTANE-2,4-DIOL | non-polymer | 118.2 | 2 | Chemie (MRD) | |||
| 4 | E (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 5 | F (A) | water | water | 18.0 | 58 | Chemie (HOH) |
Sequence modifications
A: 17 - 78 (UniProt: P00383)
| PDB | External Database | Details |
|---|---|---|
| Asp 21 | Asn 21 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 6733.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 909.9 | |
| All* | Total formula weight | 7643.4 |
