6NVJ
FGFR4 complex with N-(2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-3-fluorophenyl)acrylamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fibroblast growth factor receptor 4 | polymer | 300 | 33867.2 | 1 | UniProt (P22455) Pfam (PF07714) | Homo sapiens (Human) | FGFR-4 |
| 2 | B, C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 3 | F (A) | N-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-fluorophenyl]propanamide | non-polymer | 495.3 | 1 | Chemie (XL5) | |||
| 4 | G (A) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
A: 450 - 742 (UniProt: P22455)
| PDB | External Database | Details |
|---|---|---|
| Met 449 | - | expression tag |
| - | Pro 570 | deletion |
| - | Asp 571 | deletion |
| - | Leu 572 | deletion |
| - | Ser 573 | deletion |
| - | Pro 574 | deletion |
| - | Asp 575 | deletion |
| - | Gly 576 | deletion |
| - | Pro 577 | deletion |
| - | Arg 578 | deletion |
| His 743 | - | expression tag |
| His 744 | - | expression tag |
| His 745 | - | expression tag |
| His 746 | - | expression tag |
| His 747 | - | expression tag |
| His 748 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33867.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 879.6 | |
| All* | Total formula weight | 34746.8 |
