6NVI

FGFR4 complex with N-(3-chloro-2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-5-fluorophenyl)acrylamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Fibroblast growth factor receptor 4	polymer	300	33867.2	1	UniProt (P22455) Pfam (PF07714) In PDB	Homo sapiens (Human)	FGFR-4
2	A	N-[3-chloro-2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-5-fluorophenyl]propanamide	non-polymer		529.8	1	Chemie (XL7)
3	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4		water	water		18.0	37	Chemie (HOH)

Sequence modifications

A: 450 - 742 (UniProt: P22455)

PDB	External Database	Details
Met 449	-	expression tag
-	Pro 570	deletion
-	Asp 571	deletion
-	Leu 572	deletion
-	Ser 573	deletion
-	Pro 574	deletion
-	Asp 575	deletion
-	Gly 576	deletion
-	Pro 577	deletion
-	Arg 578	deletion
His 743	-	expression tag
His 744	-	expression tag
His 745	-	expression tag
His 746	-	expression tag
His 747	-	expression tag
His 748	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33867.2
Non-Polymers*	Number of molecules	2
	Total formula weight	625.8
All*	Total formula weight	34493.0

*Water molecules are not included.