6NQ2
Cryo-EM structure of human TPC2 channel in the ligand-bound closed state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Two pore calcium channel protein 2 | polymer | 756 | 85671.8 | 2 | UniProt (Q8NHX9) Pfam (PF00520) | Homo sapiens (Human) | Voltage-dependent calcium channel protein TPC2 |
| 2 | C, D (A, B) | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate | non-polymer | 746.6 | 2 | Chemie (EUJ) |
Sequence modifications
A, B: 1 - 752 (UniProt: Q8NHX9)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Glu 0 | - | expression tag |
| Ala 11 | Leu 11 | conflict |
| Ala 12 | Leu 12 | conflict |
| Pro 564 | Leu 564 | conflict |
| Glu 734 | Gly 734 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 171343.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1493.1 | |
| All* | Total formula weight | 172836.8 |
