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6NPZ

Crystal structure of Akt1 (aa 123-480) kinase with a bisubstrate

Replaces:  6C0I
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
RAC-alpha serine/threonine-protein kinasepolymer35841393.82UniProt (P31749)
Pfam (PF00069)
Pfam (PF00433)
Homo sapiens (Human)Protein kinase B,PKB,Protein kinase B alpha,PKB alpha,Proto-oncogene c-Akt,RAC-PK-alpha
2C, D
(F, G)
bisubstratepolymer101685.52Homo sapiens (Human)
3E, J, K, L
(A, B, F, G)
MANGANESE (II) IONnon-polymer54.94Chemie (MN)
4F, G
(A)
TRIETHYLENE GLYCOLnon-polymer150.22Chemie (PGE)
5H
(B)
GLYCEROLnon-polymer92.11Chemie (GOL)
6I
(B)
VANADATE IONnon-polymer114.91Chemie (VO4)
7M, N, O, P
(A, B, F, G)
waterwater18.0475Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight86158.6
Non-Polymers*Number of molecules8
Total formula weight727.1
All*Total formula weight86885.7
*Water molecules are not included.

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PDB entries from 2024-11-13

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